UNDERSTANDING ALLERGIES

The word ‘allergy’ is an ancient Greek term for an abnormal response or over-reaction. Contrary to popular belief, weak or deficient immune systems don’t cause asthma or allergy ailments. Rather, your body’s defenses work overtime, making your immune system too sensitive to substances that pose no real threat to your well-being, such as pollen or cat proteins. That’s why physicians often use the term hypersensitivity to refer to an allergy.

This hypersensitivity is often caused by an imbalance in ‘T-cells’ – specialized cells that regulate your immune system. Some T-cells (called “helper cells’ or ‘CD4+ cells’) activate the immune response – which is necessary to fight off disease. Another type of T-cell (called ‘suppressor cells’, or ‘CD8+ cells’) prevents the immune system from being too sensitive. Clearly a proper balance between the two types of cells – helper and suppressor – is important.

In people with allergic disease, the immune system over-reacts to allergens such as ragweed because it has too few suppressor cells relative to the amount of helper cells. This imbalance results in too much IgE production, thereby causing allergy symptoms. Cobalamin-deficiency appears to reduce the number of suppressor cells. The administration of cobalamin (the active ingredient in PreHistin™) can reverse this by increasing the number of these suppressor cells.

PreHistin™ is believed to restore the T-cell balance to one which would normally be found in non-allergic individuals.

How Allergy Symptoms Develop

If you are predisposed to developing allergies, here’s how a typical sensitization process and allergic reaction can develop, using ragweed pollen, one of the most common triggers of seasonal allergic rhinitis (also known as hay fever) as an example.

1.	Ragweed pollen enters your body, usually as a result of inhaling it through your nose.
2.	Your immune system detects the presence of these foreign substances (allergens) in your body and stimulates the production of IgE (immunoglobulin E) antibodies, a special type of antibody designed to counter specific foreign substances once you have been exposed to them. Generally, people with elevated IgE antibodies exhibit allergic response.
3.	IgE antibodies attach themselves to the surfaces of specialized cells (called mast cells) that line the tissues throughout your body, especially in your nose, eyes, lungs and skin, waiting to detect the specific allergen (the ragweed pollen) when it enters your body.

 

4.

Your immune system is a magnificent memory machine: After sensitization (your first exposure to ragweed pollen) occurs, you’ll likely experience allergies to that substance for most of your life. Think of IgE antibodies as a lock on the mast cell surface, and the ragweed pollen allergen as the key. When the ragweed allergen connects with IgE antibodies on the mast cell surface, an IgE-allergen reaction unlocks the mast cell to release its contents.

Unlocking the mast cells initiates the secretion and over-production of histamine and other potent chemical mediators of inflammation as a defensive response to the allergen. In turn, the actions of these chemicals trigger the swelling and inflammation that results in familiar allergy symptoms.

IgE Triggers Histamine Release Resulting in Allergy Symptoms PreHistin™ is Intended to Prevent the Over-Production of IgE

In short, it is the over-production of IgE antibodies that causes the eventual eruption of your allergy symptoms. If IgE overproduction could be eliminated, it would prevent your allergy symptoms from arising in the first place, and thus eliminate your need for antihistamines or other allergy symptom-fighting medications.

Antihistamines act to block the effects of histamine only after histamine has already been released. PreHistin™ is the first product ever to prevent the over-production of IgE and thus prevent a significant release of symptom-causing histamine in the first place.

Antihistamines often result in uncomfortable and annoying side effects, such as drowsiness or sedation, headache, dry mouth, constipation, dizziness, disturbed sleep and overexcitement in children. PreHistin™ has none of these side effects.

Read PREHISTIN™ MECHANISM
OF ACTIONS